INTRODUCTION. Introduction to radioembolization for the treatment of non-resectable liver cancer. PATIENT SELECTION AND TREATMENT PLANNING. Treatment options for patients with primary and secondary liver cancer: An overview of invasive, minimally invasive and non-invasive techniques. Treatment planning part I: Vascular considerations. Treatment planning part II: Procedure simulation using 99mTc-MAA. Treatment planning part III: Dosimetric considerations in conventional lobar therapy. Treatment planning part IV: Radioembolization in segmentectomy, lobectomy and future liver remnant hypertrophy. TREATING PATIENTS WITH RADIOEMBOLIZATION. Radiation safety concerns associated with preparing the dose, treating and releasing the patient and managing radioactive waste. The radiation biology of radioembolization. Glass and resin microspheres: An analysis on a microscopic and macroscopic level. FOLLOWING PATIENTS TREATED WITH RADIOEMBOLIZATION. Quantitative post-radioembolization imaging using Bremsstrahlung SPECT. Quantitative post-radioembolization imaging using PET/CT. Image-based 3-dimensional dosimetry following radioembolization. Diagnostic reporting using post-radioembolization imaging. Using post-treatment imaging in the medical management of patients treated with radioembolization. The potential utility of serial therapy in radioembolization: A radiation biology analysis. NEW HORIZONS. Future directions in radioembolization for intrahepatic and extrahepatic treatment of disease